Article

Mapping <i>cis</i> - and <i>trans</i> -regulatory target genes of human-specific deletions

2023-12-28

Abstract excerpt

Deletion of functional sequence is predicted to represent a fundamental mechanism of molecular evolution 1,2 . Comparative genetic studies of primates 2,3 have identified thousands of human-specific deletions (hDels), and the cis -regulatory potential of short (≤31 base pairs) hDels has been assessed using reporter assays 4 . However, how structural variant-sized (≥50 base pairs) hDels influence molecular and...

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Literature Corpus work: 4b83d839-5649-50cc-9a62-193bddd735f3
DOI: 10.1101/2023.12.27.573461

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