Article

Molecular mechanism of KAP1-dependent transcriptional silencing

2019-01-01

Abstract excerpt

Retroviruses can integrate their DNA into the host-cell genome. Inherited retroviral DNA and other transposable elements account for at least half of the human genome. Transcription of transposable elements is tightly regulated to restrict their proliferation and prevent toxic gene expression. A major factor contributing to the repression of potentially harmful retroelements is KRAB-associated protein 1 (KAP1, als...

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Literature Corpus work: 84fcfb10-f026-51bc-99ac-70f0ce186de3
DOI: 10.17863/cam.59801

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