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Article

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.

Nucleic acids research - 2 Nov 2018

Samson Camille, Petitalot Ambre, Celli Florian, Herrada Isaline, Ropars Virginie, Le Du Marie-Hélène, Nhiri Naïma, Jacquet Eric, Arteni Ana-Andrea, Buendia Brigitte, Zinn-Justin Sophie

Abstract excerpt

Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no structural data highlights how they interact with their partners at the interface between the inner nuclear envelope and chromatin. A large number of mutations causing rare genetic disorders called laminopathies were identified in the C-terminal globular Igfold domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30137533
DOI: 10.1093/nar/gky736
PMCID: PMC6212729

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Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.PMID 30137533Read ↗

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