Article

Molecular relationships between SARS-CoV-2 Spike protein and LIFR, a pneumonia protective IL-6 family cytokine receptor

2021-04-19

Abstract excerpt

The fine-tuned control of immune responses is attained by pairs of activating and inhibitory signaling receptors which modulate the quality and magnitude of immune responses. Some viruses exploit these pathways to enter host cells as well as interfere with immune responses. Here, we report that the SARS-CoV-1/2 Spike proteins (S) contain a potential inhibitory tyrosine- based immunoreceptor motif (ITIM) with the D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84cfced7-2ab9-5337-bebb-f8bfb2369a7d
DOI: 10.1101/2021.04.18.440296

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular relationships between SARS-CoV-2 Spike protein and LIFR, a pneumonia protective IL-6 family cytokine receptorDOI 10.1101/2021.04.18.440296Read

Interplay of TLR4 and SARS-CoV-2: Unveiling the Complex Mechanisms of Inflammation and Severity in COVID-19 InfectionsSemantic proximity Read

COVID-19db linkage maps of cell surface proteins and transcription factors in immune cellsSemantic proximity Read

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read

Interaction network of SARS-CoV-2 with host receptome through spike proteinSemantic proximity Read

STAT1 and Its Crucial Role in the Control of Viral InfectionsSemantic proximity Read

Role of SARS-CoV-2 in altering the RNA binding protein and miRNA directed post-transcriptional regulatory networks in humansSemantic proximity Read

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spikeSemantic proximity Read

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signalingSemantic proximity Read

Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce interferon-dependent inflammationSemantic proximity Read

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitroSemantic proximity Read

IL4I1 binds to TMPRSS13 and competes with SARS-Cov2 SpikeSemantic proximity Read

Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeuticsSemantic proximity Read