Article

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

2022-11-13

Abstract excerpt

<h4>Summary</h4> Altered myeloid inflammation and lymphopenia are hallmarks of severe infections, including SARS-CoV-2. Here, we identified a gene program, defined by correlation with EN-RAGE ( S100A12 ) gene expression, which was up-regulated in patient airway and blood myeloid cells. The EN-RAGE program was expressed in 7 cohorts and observed in patients with both COVID-19 and acute respiratory distress syndrome...

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Literature Corpus work: 10b7a252-7ca1-51f3-b0f4-19a9719133cb
DOI: 10.1101/2022.11.07.22282049

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