Article

Sex-Specific Pathophysiological Signatures in Allometric Dosing-Controlled Bleomycin Acute Lung Injury Model

2026-03-12

Abstract excerpt

<h4>Introduction</h4> In acute lung injury (ALI), clinical data show that while mortality rates are similar between sexes, women require shorter ventilation times and intensive care unit stays than men, yet preclinical studies show conflicting sex-specific vulnerabilities. We reasoned that a hidden dosing bias may explain the inconsistency, as intratracheal bleomycin is scaled to body weight, even though lung mas...

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Literature Corpus work: 84c89420-130f-5243-b7d7-e591944cf560
DOI: 10.64898/2026.03.10.710851

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