Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model.

Scientific reports - 27 Jun 2017

Piñeiro-Hermida Sergio, López Icíar P, Alfaro-Arnedo Elvira, Torrens Raquel, Iñiguez María, Alvarez-Erviti Lydia, Ruíz-Martínez Carlos, Pichel José G

Abstract excerpt

IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is implicated in pulmonary diseases such as cancer, ARDS, COPD, asthma and fibrosis. Here we report that lung transcriptome analysis in mice with a postnatally-induced Igf1r gene deletion showed differentially expressed genes with potentially protective roles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lung Injury
Share to Bleomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capillary Permeability

Share to Cell Proliferation

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Inflammation

Share to Mice, Transgenic

Share to Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28655914
DOI: 10.1038/s41598-017-04561-4
PMCID: PMC5487362

Genes

SFTPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model.PMID 28655914Read ↗

Transcriptomics of acute injured lungs reveals IGF1R action on DNA damage response, metabolic reprogramming, mitochondrial homeostasis and epigeneticsSemantic proximity Read ↗

Transcriptome Analysis in Prenatal IGF1-Deficient Mice Identifies Molecular Pathways and Target Genes Involved in Distal Lung DifferentiationSemantic proximity Read ↗

Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other OrgansSemantic proximity Read ↗

A new perspective on idiopathic pulmonary fibrosis research: From multi-dimensional mechanistic exploration to advances in precision therapy.Semantic proximity Read ↗

Loss of interferon regulatory factor-1 prevents lung fibrosis by upregulation of pon1 expressionSemantic proximity Read ↗

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell RegenerationSemantic proximity Read ↗

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosisSemantic proximity Read ↗

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung MorphogenesisSemantic proximity Read ↗

Highly Calibrated Relationship Between Bleomycin Concentrations and Facets of the Active Phase Fibrosis in Classical Mouse Bleomycin ModelSemantic proximity Read ↗

Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat modelSemantic proximity Read ↗

Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ FibrosisSemantic proximity Read ↗

Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary DysplasiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.