Article

Monocrotaline treatment of the rat predisposes to altered lipopolysaccharide-induced lung responses

2025-12-23

Abstract excerpt

<h4>ABSTRACT</h4> There is a need to understand pathogen driven lung disease and the rat is a laboratory model, widely used to study acute lung injury (ALI). Here the monocrotaline (MCT) rat has been investigated as a model of an inflammatory lung with developing pulmonary hypertension (PH) on which an ALI is superimposed. 14 days following a single systemic dose of MCT, the lung is functionally normal, but stimu...

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Literature Corpus work: e3b88342-4c21-57f3-a2b5-2868ac8136a2
DOI: 10.64898/2025.12.21.695829

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