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Article

Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males.

Nature communications - 12 Dec 2022

Wilson Laura A B, Zajitschek Susanne R K, Lagisz Malgorzata, Mason Jeremy, Haselimashhadi Hamed, Nakagawa Shinichi

Abstract excerpt

Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research targeted at improving treatment, increasing health span, and reducing the financial burden of health care, has mostly been conducted on male animals and cells. The extent to which sex differences in phenotypic traits are explained by sex differences in body weight remains unclear. We quantify sex differences in the...

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Identifiers

PMID: 36509767
DOI: 10.1038/s41467-022-35266-6
PMCID: PMC9744842

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