Article

Stratified cohorts for biomarker assessment and trial readiness: <i>TMEM175</i> , <i>SCARB2</i> and <i>CTSB</i> in Parkinson’s disease

2026-06-25

Abstract excerpt

<h4>Background</h4> Lysosomal dysfunction plays a crucial role in the pathogenesis of Parkinson’s disease (PD), particularly among GBA1 mutation carriers. Beyond GBA1 , genes such as TMEM175 , SCARB2 , and CTSB identified in genome-wide association studies (GWAS) are also implicated in lysosomal pathways contributing to PD risk, although their functional effects in patients remain unclear. Proteins encoded b...

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Literature Corpus work: 84be0454-9b95-57b3-bc54-e2bb8c1265a9
DOI: 10.64898/2026.06.23.26356322

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