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TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations

2 Dec 2025

Abstract excerpt

Genome-wide association study of Parkinson's disease (PD) identified common variants associated with lysosomal mechanism, including TMEM175, SCARB2, and CTSB. We investigated the association between common and rare variants across populations using cohorts from the Global Parkinson's Genetics Program (GP2) (33,733 cases and 18,703 controls from ten ancestries). In the European cohort, we confirmed significant...

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PMID: 41331295
DOI: 10.1038/s41531-025-01180-z

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