Comparative lifespan trajectories of brain energy metabolism in human and macaque

Abstract excerpt

The brain's extraordinary energy demands are met by a suite of metabolic pathways that selectively appropriate glucose across development, yet how this metabolic strategy changes across the lifespan and whether it is conserved across species remains incompletely understood. We previously mapped five core energy metabolism pathways across the human cortex and lifespan, revealing a fundamental dichotomy between anab...

Topics

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• Biological Evolution
• Brain
• Diet and metabolism studies
• Gene Expression Profiling
• Mitochondrial Function and Pathology
• Neuroimaging
• Phenotype
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

8dfdd869-161c-594d-86a8-a2d954abc68f

DOI

10.64898/2026.04.16.719061