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Article

Brain metabolic and functional alterations in a liver-specific PTEN knockout mouse model.

PloS one - 1 Jan 2018

Patil Ishan, Sancheti Harsh, Stiles Bangyan L, Cadenas Enrique

Abstract excerpt

Insulin resistance-as observed in aging, diabetes, obesity, and other pathophysiological situations, affects brain function, for insulin signaling is responsible for neuronal glucose transport and control of energy homeostasis and is involved in the regulation of neuronal growth and synaptic plasticity. This study investigates brain metabolism and function in a liver-specific Phosphatase and Tensin Homologue...

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Topics

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Share to Glucose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuronal Plasticity

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Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Source

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Identifiers

PMID: 30235271
DOI: 10.1371/journal.pone.0204043
PMCID: PMC6147462

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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