Back to search

Article

Inflammatory leptomeningeal cytokines mediate delayed COVID-19 encephalopathy

2020-09-18

Abstract excerpt

SARS-CoV-2 infection induces a wide spectrum of neurologic dysfunction. Here we show that a particularly vulnerable population with neurologic manifestations of COVID-19 harbor an influx of inflammatory cytokines within the cerebrospinal fluid in the absence of viral neuro-invasion. The majority of these inflammatory mediators are driven by type 2 interferon and are known to induce neuronal injury in other disease...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
16d13b60-78e5-502c-8221-b2c7f9dfe776
DOI
10.1101/2020.09.15.20195511
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inflammatory leptomeningeal cytokines mediate delayed COVID-19 encephalopathyDOI 10.1101/2020.09.15.20195511
COVID-19-Associated Encephalitis: Systematic Review of Case ReportsFindings on Cytokine-Immune-Mediated Inflammation as an Underlying MechanismSemantic proximity
The Brain Reacting to COVID-19: Analysis of the Cerebrospinal Fluid and Serum Proteome,Transcriptome and Inflammatory ProteinsSemantic proximity
Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromesSemantic proximity
SARS-CoV-2 Impact on the Central Nervous System: Are Astrocytes and Microglia Main Players or Merely Bystanders?Semantic proximity
Persistent Neurological Symptoms After COVID-19 Lack Evidence of Adaptive CNS Immune ActivationSemantic proximity
The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2Semantic proximity
SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous systemSemantic proximity
The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illnessSemantic proximity
The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illnessSemantic proximity
Molecular Neuropathology and Cerebrospinal Fluid Diagnostic Biomarkers of SARS-Cov2 Infection in Central Nervous System– A Scoping Review ProtocolSemantic proximity
An Inflammatory Signature Associated with Genetic Predisposition to Acute Necrotizing EncephalopathySemantic proximity
Elevation of Neuronal Injury Markers in Patients with Neurologic Sequelae after Hospitalization for SARS-CoV-2 Infection: A Biomarker Pilot StudySemantic proximity
Select a neighboring publication to make it the new centre.