Article

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant Infection

2024-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Viral variant is one known risk factor associated with post-acute sequelae of COVID-19 (PASC), yet the pathogenesis is largely unknown. Here, we studied SARS-CoV-2 Delta variant-induced PASC in K18-hACE2 mice. The virus replicated productively, induced robust inflammatory responses in lung and brain tissues, and caused weight loss and mortality during the acute infection. Longitudinal behavior s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6475f3b9-4cf4-5a54-a911-bf7606e2adf8
DOI: 10.1101/2024.01.03.574064

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant InfectionDOI 10.1101/2024.01.03.574064Read

Delta (B1.617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 miceSemantic proximity Read

Neurobiological Alterations Induced by SARS-CoV-2: Insights from Variant-Specific Host Gene Expression Patterns in hACE2-Expressing MiceSemantic proximity Read

A Mouse Model of SARS-CoV-2-Driven Acute Maladaptive Responses and Chronic Systemic DiseasesSemantic proximity Read

Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistenceSemantic proximity Read

The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanSemantic proximity Read

Delayed viral clearance and altered inflammatory responses resulted in increased severity of SARS-CoV-2 infection in aged miceSemantic proximity Read

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 miceSemantic proximity Read

Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine modelSemantic proximity Read

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19Semantic proximity Read

A Longitudinal SARS-CoV-2 Biorepository for COVID-19 Survivors with and without Post-Acute SequelaeSemantic proximity Read

Mechanisms of sex differences in acute and long COVID sequelae in miceSemantic proximity Read

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing miceSemantic proximity Read