Article

Gallocatechin restores HNF4A-associated metabolic regulation and alleviates rifampicin-induced liver injury

2026-08-04

Abstract excerpt

<h4>Background: </h4> and Purpose Rifampicin is a first-line anti-tuberculosis drug and a clinically important cause of drug-induced liver injury. The molecular mechanisms underlying its hepatotoxicity involves diverse pathological manifestations and remains incompletely understood. Hepatocyte nuclear factor 4 alpha (HNF4A) is a liver-enriched transcription factor that plays essential roles in maintaining hepatocy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84b157a8-4d15-57ef-8b51-0afbe26ec1f3
DOI: 10.22541/authorea.15006991/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gallocatechin restores HNF4A-associated metabolic regulation and alleviates rifampicin-induced liver injuryDOI 10.22541/authorea.15006991/v1Read

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical modelSemantic proximity Read

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read

Liver-directed AAV gene therapy metabolically corrects AKU in <i>Hgd</i> deficient miceSemantic proximity Read

Suppression of hepatic amino acid catabolism by the human-specific lncRNA hLMR1Semantic proximity Read

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized MiceSemantic proximity Read

Hepatocyte Nuclear Factor 4α Regulates Rifampicin-Mediated Induction of CYP2C Genes in Primary Cultures of Human HepatocytesSemantic proximity Read

MiR-155-5p Elevated by Ochratoxin A Induces Intestinal Fibrosis and Epithelial-to-Mesenchymal Transition through TGF-β Regulated Signaling Pathway In Vitro and In VivoSemantic proximity Read

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male miceSemantic proximity Read

A microbial metabolite reduces alcohol-induced inflammation via dual modulation of NF-κB and Interferon pathwaySemantic proximity Read

Influence of HNF4α and HNF4α-AS1 gene variants on the risk of anti-tuberculosis drugs-induced hepatotoxicity.Semantic proximity Read

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read

Regulation of MicroRNA Expression by Rifampin in Human HepatocytesSemantic proximity Read