Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

25 Aug 2021

Abstract excerpt

BACKGROUND & AIMS: Therapeutic targeting of injuries that require transient restoration of proteins by mRNA delivery is an attractive approach that, until recently, has remained poorly explored. In this study, we examined the therapeutic utility of mRNA delivery for liver fibrosis and cirrhosis. Specifically, we aimed to demonstrate the therapeutic efficacy of human hepatocyte nuclear factor alpha (HNF4A) mRNA in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver Disease Diagnosis and Treatment
Share to Liver physiology and pathology
Share to Paraoxonase enzyme and polymorphisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34453962
DOI: 10.1016/j.jhep.2021.08.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical modelPMID 34453962Read ↗

Gallocatechin restores HNF4A-associated metabolic regulation and alleviates rifampicin-induced liver injurySemantic proximity Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver FailureSemantic proximity Read ↗

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.Semantic proximity Read ↗

Targeting EIF5A improves liver fibrosis by inhibiting mitochondrial function of hepatic stellate cellsSemantic proximity Read ↗

Emerging mRNA Technology for Liver Disease TherapySemantic proximity Read ↗

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor RegressionSemantic proximity Read ↗

Progressive loss of hepatocyte nuclear factor 4 alpha activity in chronic liver diseases in humansSemantic proximity Read ↗

mRNA-Based Approaches to Treating Liver DiseasesSemantic proximity Read ↗

lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilizationSemantic proximity Read ↗

RNA nanotherapeutics for hepatocellular carcinoma treatmentSemantic proximity Read ↗

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.