Article

Disparities in cancer genomics by ancestry in the 100,000 Genomes Project

2024-11-15

Abstract excerpt

<h4>Purpose</h4> Most research on genetic screening and precision oncology is based on participants of European ancestry, making it vital to evaluate the performance of these approaches in diverse populations. We analysed data from the 100,000 Genomes Project (100kGP) to assess ancestry-related differences in cancer variant prioritisation. <h4>Patients and Methods</h4> To assess the representativeness of the 14,77...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84a54d99-4844-53be-a7ee-f9ac870914fd
DOI: 10.1101/2024.11.14.24317310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disparities in cancer genomics by ancestry in the 100,000 Genomes ProjectDOI 10.1101/2024.11.14.24317310Read

Ancestry-Specific Predisposing Germline Variants in CancerSemantic proximity Read

Cancer Genomics: Diversity and Disparity Across Ethnicity and GeographySemantic proximity Read

Precision oncology and genetic ancestry: The science behind population-based cancer disparities.Semantic proximity Read

Ancestry-specific predisposing germline variants in cancer.Semantic proximity Read

Deciphering the Genomic Architecture of Three Major Cancers in African-Ancestry PopulationsSemantic proximity Read

Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort.Semantic proximity Read

Comparative Genomic Landscape of Urothelial Carcinoma of the Bladder Among Patients of East and South Asian Genomic Ancestry.Semantic proximity Read

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6.Semantic proximity Read

The clinical and molecular landscape of breast cancer in women of African and South Asian ancestrySemantic proximity Read

Ancestry-specific hereditary cancer panel yields: Moving toward more personalized risk assessment.Semantic proximity Read

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scoresSemantic proximity Read

Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancersSemantic proximity Read