Article
Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort.
Cancer discovery - 2 Nov 2022
Arora Kanika, Tran Thinh N, Kemel Yelena, Mehine Miika, Liu Ying L, Nandakumar Subhiksha, Smith Shaleigh A, Brannon A Rose, Ostrovnaya Irina, Stopsack Konrad H, Razavi Pedram, Safonov Anton, Rizvi Hira A, Hellmann Matthew D, Vijai Joseph, Reynolds Thomas C, Fagin James A, Carrot-Zhang Jian, Offit Kenneth, Solit David B, Ladanyi Marc, Schultz Nikolaus, Zehir Ahmet, Brown Carol L, Stadler Zsofia K, Chakravarty Debyani, Bandlamudi Chaitanya, Berger Michael F
Abstract excerpt
Accurate ancestry inference is critical for identifying genetic contributors of cancer disparities among populations. Although methods to infer genetic ancestry have historically relied upon genome-wide markers, the adaptation to targeted clinical sequencing panels presents an opportunity to incorporate ancestry inference into routine diagnostic workflows. We show that global ancestral contributions and admixture...
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