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Naturally-acquired and Vaccine-induced Human Monoclonal Antibodies to <i>Plasmodium vivax</i> Duffy Binding Protein Inhibit Invasion of <i>Plasmodium knowlesi</i> (PvDBPOR) Transgenic Parasites

2023-03-09

Abstract excerpt

<h4>ABSTRACT</h4> The Duffy antigen receptor for chemokines (DARC) expressed on erythrocytes is central to Plasmodium vivax (Pv) invasion of reticulocytes. Pv expresses a Duffy binding protein (PvDBP) on merozoites, a DARC ligand, and their protein-protein interaction is central to vivax blood stage malaria. Here we compared the functional activity of humAbs derived from naturally exposed and vaccinated individu...

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Literature Corpus work
849a9955-1999-5b25-b8f0-8ec273c5b800
DOI
10.1101/2023.03.07.531647
Open publication

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Naturally-acquired and Vaccine-induced Human Monoclonal Antibodies to <i>Plasmodium vivax</i> Duffy Binding Protein Inhibit Invasion of <i>Plasmodium knowlesi</i> (PvDBPOR) Transgenic ParasitesDOI 10.1101/2023.03.07.531647
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