Article

Computational Analysis of the Metal Selectivity of Matrix Metalloproteinase 8

2020-07-01

Abstract excerpt

Matrix metalloproteinase (MMP) is a class of metalloenzyme that cleaves peptide bonds in extracellular matrices. Their functions are important in both health and disease of animals. Here using quantum mechanics simulations of the MMP8 protein, the coordination chemistry of different metal cofactors is examined. Comparisons found that Jhan-Teller effects in Cu(II) destabilize the wild-type MMP8 but a histidine to g...

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Literature Corpus work: 8491df69-ccb8-562a-a675-4ded6f04432b
DOI: 10.1101/2020.06.30.165720

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