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Article

Identification of an Electrostatic Ruler Motif for Sequence-Specific Binding of Collagenase to Collagen.

The journal of physical chemistry. B - 25 Aug 2016

Subramanian Sundar Raman, Singam Ettayapuram Ramaprasad Azhagiya, Berinski Michael, Subramanian Venkatesan, Wade Rebecca C

Abstract excerpt

Sequence-specific cleavage of collagen by mammalian collagenase plays a pivotal role in cell function. Collagenases are matrix metalloproteinases that cleave the peptide bond at a specific position on fibrillar collagen. The collagenase Hemopexin-like (HPX) domain has been proposed to be responsible for substrate recognition, but the mechanism by which collagenases identify the cleavage site on fibrillar collagen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27245212
DOI: 10.1021/acs.jpcb.6b02573

Genes

HPX

Provenance

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