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Article

Metal Ion Capture Mechanism of a Copper Metallochaperone.

Biochemistry - 26 Jan 2016

Chakravorty Dhruva K, Li Pengfei, Tran Trang T, Bayse Craig A, Merz Kenneth M

Abstract excerpt

A novel cation-π interaction between the bound Cu(+) metal ion and Trp44 in the periplasmic Cu(+)/Ag(+) metallochaperone Escherichia coli CusF protects Cu(+) from the oxidative influence of the periplasm. In a popular model of metal ion transfer, a conformational change in the metal binding loop disrupts the cation-π interaction and moves Trp44 aside to provide access to the occluded metal ion binding site in an...

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Identifiers

PMID: 26690586
DOI: 10.1021/acs.biochem.5b01217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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