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Article

Exploration of the zinc finger motif in controlling activity of matrix metalloproteinases.

The journal of physical chemistry. B - 26 Nov 2014

Khrenova Maria G, Savitsky Alexander P, Topol Igor A, Nemukhin Alexander V

Abstract excerpt

Discovering ways to control the activity of matrix metalloproteinases (MMPs), zinc-dependent enzymes capable of degrading extracellular matrix proteins, is an important field of cancer research. We report here a novel strategy for assembling MMP inhibitors on the basis of oligopeptide ligands by exploring the pattern known as the zinc finger motif. Advanced molecular modeling tools were used to characterize the...

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Identifiers

PMID: 25375834
DOI: 10.1021/jp5088702
PMCID: PMC4254000

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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