Article

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

2022-09-20

Abstract excerpt

Leptomeningeal metastasis is associated with dismal prognosis and has few treatment options. However, very little is known about the immune response to leptomeningeal metastasis. Here, by establishing an immunocompetent mouse model of breast cancer leptomeningeal metastasis, we found that tumor-specific CD8 + T cells were generated in deep cervical lymph nodes (dCLNs) and played an important role in controlling l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10aeb587-eb0f-5d46-bd16-dec718c69e63
DOI: 10.1101/2022.09.20.508709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasisDOI 10.1101/2022.09.20.508709Read

Leptomeningeal anti-tumor immunity follows unique signaling principlesSemantic proximity Read

Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40Semantic proximity Read

Transcriptional profiling reveals a previously unknown population of Cdkn2a-positive tumor-associated macrophages in aggressive brain cancerSemantic proximity Read

Immune characteristics associated with lymph node metastasis in early-stage NSCLCSemantic proximity Read

Characterisation of immune cell subsets of tumour infiltrating lymphocytes in brain metastasesSemantic proximity Read

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph NodesSemantic proximity Read

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastasesSemantic proximity Read

Tumor-Associated Macrophages Promote Brain MetastasisSemantic proximity Read

The cellular and molecular origin of tumor-associated macrophagesSemantic proximity Read

Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node nicheSemantic proximity Read

Alzheimer disease and Apolipoprotein E4: meningeal brain lymphatics point to new clues in pathogenesisSemantic proximity Read

Lymphatic PD-L1 expression restricts tumor-specific CD8 <sup>+</sup> T cell responsesSemantic proximity Read