Article
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.
Blood - 17 Jul 2014
Rajasagi Mohini, Shukla Sachet A, Fritsch Edward F, Keskin Derin B, DeLuca David, Carmona Ellese, Zhang Wandi, Sougnez Carrie, Cibulskis Kristian, Sidney John, Stevenson Kristen, Ritz Jerome, Neuberg Donna, Brusic Vladimir, Gabriel Stacey, Lander Eric S, Getz Gad, Hacohen Nir, Wu Catherine J
Abstract excerpt
Genome sequencing has revealed a large number of shared and personal somatic mutations across human cancers. In principle, any genetic alteration affecting a protein-coding region has the potential to generate mutated peptides that are presented by surface HLA class I proteins that might be recognized by cytotoxic T cells. To test this possibility, we implemented a streamlined approach for the prediction and...
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