Article

Evolutionary analysis of mammalian Rem2, a member of the RGK (Rem, Rem2, Rad, and Gem/Kir) family of small GTPases, reveals the role of selection and epistasis in shaping protein functional constraints

2023-08-29

Abstract excerpt

Rad And Gem-Like GTP-Binding Protein 2 (Rem2) , is a member of the RGK family of Ras-like GTPases and has been identified in various mammalian species. Rem2 has been implicated in Huntington’s disease and Long QT Syndrome and is highly expressed in the brain and in endocrine cells. In this study, we examined the evolutionary history of Rem2 across mammals, focusing on the role of purifying selection and epistasi...

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Literature Corpus work: 845c1d41-0773-5cd9-98c7-da972818e1b6
DOI: 10.1101/2023.08.28.555117

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Evolutionary analysis of mammalian Rem2, a member of the RGK (Rem, Rem2, Rad, and Gem/Kir) family of small GTPases, reveals the role of selection and epistasis in shaping protein functional constraintsDOI 10.1101/2023.08.28.555117Read

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