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A <i>Drosophila in vivo</i> chemical screen reveals that combination drug treatment targeting MEK and DGKα mitigates Ras-driven polarity-impaired tumourigenesis

2022-03-16

Abstract excerpt

The RAS oncogene and upregulation of the RAS signalling pathway is highly prevalent in human cancer, and therefore, therapeutically targeting the RAS pathway is a common treatment in cancer. However, RAS pathway upregulation is not sufficient to drive malignant cancer, since senescence mechanisms prevent cancer progression. Thus, additional mutations, such as mutations that prevent senescence or alter the tissue...

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Literature Corpus work
844efb24-9df8-5465-9ed6-9473838ce772
DOI
10.1101/2022.03.14.484232
Open publication

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A <i>Drosophila in vivo</i> chemical screen reveals that combination drug treatment targeting MEK and DGKα mitigates Ras-driven polarity-impaired tumourigenesisDOI 10.1101/2022.03.14.484232
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