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Article

Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics.

Oncotarget - 28 Jun 2016

Fernandez Del Ama Laura, Jones Mary, Walker Paul, Chapman Anna, Braun Julia A, Mohr Jasmine, Hurlstone Adam F L

Abstract excerpt

Phenotype-guided re-profiling of approved drug molecules presents an accelerated route to developing anticancer therapeutics by bypassing the target-identification bottleneck of target-based approaches and by sampling drugs already in the clinic. Further, combinations incorporating targeted therapies can be screened for both efficacy and toxicity. Previously we have developed an oncogenic-RAS-driven zebrafish...

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Identifiers

PMID: 27248171
DOI: 10.18632/oncotarget.9613
PMCID: PMC5130012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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