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Article

A CRISP(e)R view on kidney organoids allows generation of an induced pluripotent stem cell-derived kidney model for drug discovery.

Kidney international - 1 Dec 2018

Boreström Cecilia, Jonebring Anna, Guo Jing, Palmgren Henrik, Cederblad Linda, Forslöw Anna, Svensson Anna, Söderberg Magnus, Reznichenko Anna, Nyström Jenny, Patrakka Jaakko, Hicks Ryan, Maresca Marcello, Valastro Barbara, Collén Anna

Abstract excerpt

Development of physiologically relevant cellular models with strong translatability to human pathophysiology is critical for identification and validation of novel therapeutic targets. Herein we describe a detailed protocol for generation of an advanced 3-dimensional kidney cellular model using induced pluripotent stem cells, where differentiation and maturation of kidney progenitors and podocytes can be...

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Cell Lineage
CRISPR-Cas Systems
Drug Discovery
Gene Editing
High-Throughput Screening Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Induced Pluripotent Stem Cells

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PMID: 30072040
DOI: 10.1016/j.kint.2018.05.003

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NPHS1
SIX2

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