Article

The Impact of Obesity-Related Genetic Variants on NF-κB Signaling in Cardiovascular Disease: A Systematic Review

2024-12-11

Abstract excerpt

<h4>Objective</h4> To investigate how genetic variations in obesity-related genes (FTO, MC4R, LEP, LEPR, PCSK1, PPARG, BDNF, SIM1, TBC1D1, ADRB3, UCP1, and SH2B1) impact the NF-κB signaling pathway, exploring mechanisms of NF-κB activation, downstream inflammatory responses, and their role in cardiovascular disease (CVD) development in the context of obesity. <h4>Background</h4> Obesity is a leading contributor to...

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Literature Corpus work: 842abdd7-9fe5-5611-999c-3f895296619f
DOI: 10.1101/2024.12.11.24318855

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