Article
Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts.
PloS one - 1 Jan 2013
Stegger Jakob Gerhard, Schmidt Erik Berg, Berentzen Tina Landsvig, Tjønneland Anne, Vogel Ulla, Rimm Eric, Sørensen Thorkild I A, Overvad Kim, Jensen Majken K
Abstract excerpt
INTRODUCTION: The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as...
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