Article

Prostratin Induces HIV Activation and Downregulates HIV Receptors in Peripheral Blood Lymphocytes

2004-05-01

Abstract excerpt

Induction of HIV expression through lymphocyte activation has been proposed as a strategy to purge latent reservoirs. Prostratin is a non-tumourogenic phorbol ester that delays HIV replication in vitro, but paradoxically activates HIV expression in latently infected cells. To get a better insight into the mechanisms of action of prostratin, we have analysed the effect of prostratin on HIV activation and HIV recept...

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Literature Corpus work: 84255ef1-71b9-5fa6-8e55-d88cc805da40
DOI: 10.1177/135965350400900415

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