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Article

Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry.

Antiviral chemistry & chemotherapy - 1 Nov 2003

Witvrouw Myriam, Pannecouque Christophe, Fikkert Valery, Hantson Anke, Van Remoortel Barbara, Hezareh Marjan, De Clercq Erik, Brown Stephen J

Abstract excerpt

Prostratin, a non-tumour promoting phorbol ester, exhibit a potent anti-HIV activity against human immunodeficiency virus type 1 (HIV-1). However, the antiviral mechanism of prostratin is not well defined. In the present study, we report that prostratin exhibits potent antiviral activity against different strains of HIV-1 (subtypes B and D), a clinical HIV isolate (L1), HIV-2 (ROD and EHO) and SIV (MAC251) with...

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PMID: 14968938
DOI: 10.1177/095632020301400604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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