Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prostratin and Bortezomib are Novel Inducers of Latent Kaposi'S Sarcoma-Associated Herpesvirus

1 Aug 2005

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes latent infections in lymphocytes and endothelial cells, and latent infection is closely linked to tumorigenesis. As few viral markers are expressed during latency, compounds that can safely and efficiently increase lytic gene expression in vivo have been sought. We have found that the non-tumour-promoting phorbol ester prostratin and the proteasome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CNS Lymphoma Diagnosis and Treatment
Share to Histiocytic Disorders and Treatments
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16218174
DOI: 10.1177/135965350501000609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prostratin and Bortezomib are Novel Inducers of Latent Kaposi'S Sarcoma-Associated HerpesvirusPMID 16218174Read ↗

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagySemantic proximity Read ↗

Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene ExpressionSemantic proximity Read ↗

Dissection of the Kaposi's Sarcoma-Associated Herpesvirus Gene Expression Program by Using the Viral DNA Replication Inhibitor CidofovirSemantic proximity Read ↗

Contribution of the KSHV and EBV lytic cycles to tumourigenesisSemantic proximity Read ↗

Prostratin Induces HIV Activation and Downregulates HIV Receptors in Peripheral Blood LymphocytesSemantic proximity Read ↗

Glycyrrhizic acid alters Kaposi sarcoma–associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytesSemantic proximity Read ↗

Glycyrrhizic acid alters Kaposi sarcoma–associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytesSemantic proximity Read ↗

NF-κB is essential for the progression of KSHV- and EBV-infected lymphomas in vivoSemantic proximity Read ↗

Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene RepressionSemantic proximity Read ↗

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus LatencySemantic proximity Read ↗

Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAARTSemantic proximity Read ↗

Concurrent Expression of Latent and a Limited Number of Lytic Genes with Immune Modulation and Antiapoptotic Function by Kaposi's Sarcoma-Associated Herpesvirus Early during Infection of Primary Endothelial and Fibroblast Cells and Subsequent Decline of Lytic Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.