Article

Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer

2020-06-14

Abstract excerpt

The silencing of tumor suppressor genes by promoter CpG island (CGI) methylation isan important cause of oncogenesis. Silencing of MLH1 and BRCA1, two examples ofoncogenic events, results from promoter CGI methylation. Interestingly, both MLH1and BRCA1 have a divergent promoter, from which another gene on the oppositestrand is also transcribed. Although studies have shown that divergent transcriptionis an impor...

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Literature Corpus work: 83fe13f0-a3aa-5563-a982-9d2a0c6b190a
DOI: 10.31234/osf.io/gn9xu

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