Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.

Scientific reports - 20 Jun 2017

Kiehl Steffen, Zimmermann Tobias, Savai Rajkumar, Pullamsetti Soni S, Seeger Werner, Bartkuhn Marek, Dammann Reinhard H

Abstract excerpt

Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation compared to normal cells. The functional annotation of hypermethylated CGI revealed that the hypermethylation was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

Share to Lung Neoplasms

Share to Tandem Repeat Sequences

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28634396
DOI: 10.1038/s41598-017-04248-w
PMCID: PMC5478622

Genes

CPSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.PMID 28634396Read ↗

Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancerSemantic proximity Read ↗

Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancerSemantic proximity Read ↗

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.Semantic proximity Read ↗

Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinomaSemantic proximity Read ↗

Clinical implications of epigenetic alterations in human thoracic malignancies: epigenetic alterations in lung cancer.Semantic proximity Read ↗

Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary diseaseSemantic proximity Read ↗

Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.Semantic proximity Read ↗

Molecular Subtypes Based on DNA Methylation Predict Prognosis in Lung Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.