Article
An intensive longitudinal examination of topiramate treatment for alcohol use disorder: a secondary analysis of data from a randomized controlled trial.
Addiction (Abingdon, England) - 1 Jun 2023
Votaw Victoria R, Witkiewitz Katie, Van Horn M Lee, Crist Richard C, Pond Timothy, Kranzler Henry R
Abstract excerpt
BACKGROUND AND AIMS: Previous findings have been equivocal as to whether a single-nucleotide polymorphism (rs2832407) in GRIK1, which encodes a glutamate receptor subunit, moderates the effects of topiramate treatment for drinking reduction. We leveraged intensive longitudinal data to provide greater precision and allow an examination of intermediate outcomes addressing this question. We used data from a...
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