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Article

Multifaceted Role of Sialylation in Prion Diseases

8 Aug 2016

Abstract excerpt

Mammalian prion or PrP(Sc) is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein, or PrP(C). Sialylation of the prion protein N-linked glycans was discovered more than 30 years ago, yet the role of sialylation in prion pathogenesis remains poorly understood. Recent years have witnessed extraordinary growth in interest in...

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PMID: 27551257
DOI: 10.3389/fnins.2016.00358

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