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Article

Tribbles 2 confers enzalutamide resistance in prostate cancer by promoting lineage plasticity

2021-03-28

Abstract excerpt

Second-generation anti-androgen, such as enzalutamide (Xtandi), is commonly prescribed for prostate cancer therapy, but enzalutamide-resistant, lethally incurable disease invariably develops. To understand the molecular basis of enzalutamide resistance, we comprehensively analyzed prostate tumors and clinically relevant models. These studies revealed that enzalutamide resistant prostate cancer cells overexpress Tr...

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Identifiers and source

Literature Corpus work
83c7d10d-7f47-56c1-8468-ce3b41888072
DOI
10.1101/2021.03.26.437250
Open publication

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Tribbles 2 confers enzalutamide resistance in prostate cancer by promoting lineage plasticityDOI 10.1101/2021.03.26.437250
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