Article

ID2 Promotes Lineage Transition of Prostate Cancer through FGFR and JAK-STAT Signaling

2023-11-29

Abstract excerpt

The use of ARPIs has led to an increase in the proportion of AR-null prostate cancer, including NEPC and DNPC, but the mechanism underlying this lineage transition has not been elucidated. We found that ID2 expression was increased in AR-null prostate cancer. In vitro and in vivo studies confirmed that ID2 promotes PCa malignancy and can confer resistance to enzalutamide in PCa cells. We generated a ID2 UP50 signa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 091ae2f9-feed-5cec-8c21-0fbd4131b7d9
DOI: 10.20944/preprints202311.1895.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ID2 Promotes Lineage Transition of Prostate Cancer through FGFR and JAK-STAT SignalingDOI 10.20944/preprints202311.1895.v1Read

Single-cell sequencing analysis revealed that NEAT1 was a potential biomarker and therapeutic target of prostate cancerSemantic proximity Read

Role of prostate cancer stem-like cells in the development of antiandrogen resistanceSemantic proximity Read

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasisSemantic proximity Read

Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate CancerSemantic proximity Read

Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemnessSemantic proximity Read

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like CharacteristicsSemantic proximity Read

Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties.Semantic proximity Read

Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancerSemantic proximity Read

Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient SurvivalSemantic proximity Read

Tribbles 2 confers enzalutamide resistance in prostate cancer by promoting lineage plasticitySemantic proximity Read

Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven 7-Gene Stemness Signature that Predicts ProgressionSemantic proximity Read

Cell division cycle 20 (CDC20) drives prostate cancer progression via stabilization of β-catenin in cancer stem-like cellsSemantic proximity Read