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Article

Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.

Science (New York, N.Y.) - 27 Sept 2002

Tomishige Michio, Klopfenstein Dieter R, Vale Ronald D

Abstract excerpt

Unc104/KIF1A belongs to a class of monomeric kinesin motors that have been thought to possess an unusual motility mechanism. Unlike the unidirectional motion driven by the coordinated actions of the two heads in conventional kinesins, single-headed KIF1A was reported to undergo biased diffusional motion along microtubules. Here, we show that Unc104/KIF1A can dimerize and move unidirectionally and processively...

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Source

Identifiers

PMID: 12351789
DOI: 10.1126/science.1073386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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