Effects of cocktail combinations of antisense oligonucleotides on potency

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The co-administration of several therapeutic oligonucleotides targeting the same transcript is a beneficial approach. It broadens the target sites for diseases associated with various mutations or splice variants. However, little is known how a combination of antisense oligonucleotides (ASOs), which is one of the major modalities of therapeutic oligonucleotides,...

Topics

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• Cytomegalovirus and herpesvirus research
• DNA and Nucleic Acid Chemistry
• Neurogenetic and Muscular Disorders Research
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• RNA Research and Splicing
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

83499b9f-90b6-5dce-9f74-df8af106e97d

DOI

10.21203/rs.3.rs-2127573/v1