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Article

Pre-mRNA Splicing Modulation by Antisense Oligonucleotides.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Singh Natalia N, Luo Diou, Singh Ravindra N

Abstract excerpt

Pre-mRNA splicing, a dynamic process of intron removal and exon joining, is governed by a combinatorial control exerted by overlapping cis-elements that are unique to each exon and its flanking intronic sequences. Splicing cis-elements are usually 4-to-8-nucleotide-long linear motifs that provide binding sites for specific proteins. Pre-mRNA splicing is also influenced by secondary and higher order RNA structures...

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Share to Neurons
Share to Oligonucleotides, Antisense
Share to Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

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Share to Survival of Motor Neuron 2 Protein

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Source

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Identifiers

PMID: 30171557
DOI: 10.1007/978-1-4939-8651-4_26
PMCID: PMC6195309

Genes

SMN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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