Article

Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition

2025-03-11

Abstract excerpt

<h4>SUMMARY</h4> T cells in the perinatal thymus have distinct phenotypes and functions that may be instructed by age-specific features of the microenvironment. We evaluated molecular and cellular profiles of thymic stromal cells, including thymic epithelial cells (TECs), mesenchyme, endothelium, and hematopoietic antigen presenting cells (hAPCs), from birth through one-month of age in mice. Single-cell transcrip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3833e71f-71f3-501a-b918-487f9b89a94b
DOI: 10.1101/2025.03.04.641047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transitionDOI 10.1101/2025.03.04.641047Read

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus OrganogenesisSemantic proximity Read

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiationSemantic proximity Read

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironmentSemantic proximity Read

Mapping the developing human immune system across organsSemantic proximity Read

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medullaSemantic proximity Read

Fetal Thymic Expression Defines the Immunogenicity of Tumor Associated AntigensSemantic proximity Read

Rediscovering the human thymus through cutting-edge technologiesSemantic proximity Read

Sex biased human thymic architecture guides T cell development through spatially defined nichesSemantic proximity Read

Thymic Epithelial CellsSemantic proximity Read

Primary and secondary defects of the thymusSemantic proximity Read

Deconstructing the Thymic Microenvironment Through Genesis to SenescenceSemantic proximity Read

Cellular and molecular events during early thymus developmentSemantic proximity Read