Article
The Integrated Genomic Landscape of Thymic Epithelial Tumors.
Cancer cell - 12 Feb 2018
Radovich Milan, Pickering Curtis R, Felau Ina, Ha Gavin, Zhang Hailei, Jo Heejoon, Hoadley Katherine A, Anur Pavana, Zhang Jiexin, McLellan Mike, Bowlby Reanne, Matthew Thomas, Danilova Ludmila, Hegde Apurva M, Kim Jaegil, Leiserson Mark D M, Sethi Geetika, Lu Charles, Ryan Michael, Su Xiaoping, Cherniack Andrew D, Robertson Gordon, Akbani Rehan, Spellman Paul, Weinstein John N, Hayes D Neil, Raphael Ben, Lichtenberg Tara, Leraas Kristen, Zenklusen Jean Claude, Fujimoto Junya, Scapulatempo-Neto Cristovam, Moreira Andre L, Hwang David, Huang James, Marino Mirella, Korst Robert, Giaccone Giuseppe, Gokmen-Polar Yesim, Badve Sunil, Rajan Arun, Ströbel Philipp, Girard Nicolas, Tsao Ming S, Marx Alexander, Tsao Anne S, Loehrer Patrick J
Abstract excerpt
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Genomics
- Humans