Article

Associations between regional blood-brain barrier disruption, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults

2024-02-21

Abstract excerpt

<h4>Background</h4> Blood-brain barrier disruption (BBBd) has been hypothesized as a feature of aging that may lead to the development of Alzheimer’s disease (AD). We sought to identify the brain regions most vulnerable to BBBd during aging and examine their regional relationship with neuroimaging biomarkers of AD. <h4>Methods</h4> We studied 31 cognitively normal older adults (OA) and 10 young adults (YA) from...

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Literature Corpus work: 831a5215-c324-5f53-84ae-06ddda1c78d0
DOI: 10.1101/2024.02.16.580788

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