Article

BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering

2026-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Clinical studies of chimeric antigen receptor (CAR)-T therapy generate diverse molecular and clinical evidence that remains fragmented across publications, public repositories and patient-derived datasets, limiting systematic therapeutic discovery. Here we present BioPathfinder, an evidence-guided multi-agent workflow for closed-loop biomedical discovery. BioPathfinder constructs a provenance-aw...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 830e50ed-506e-5c25-86cc-bd07c367894b
DOI: 10.64898/2026.07.15.738646

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineeringDOI 10.64898/2026.07.15.738646Read

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8⁺ T Cells Undetectable by Conventional AnalysesSemantic proximity Read

A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T CellsSemantic proximity Read

CAR<sup>+</sup> and CAR<sup>-</sup> T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read

The Virtual Biotech: A Multi-Agent AI Framework for Therapeutic Discovery and DevelopmentSemantic proximity Read

SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell TranscriptomicsSemantic proximity Read

Multiscale Predictive Cellular Modeling: Integrating Hypothesis Grammars, Digital Twins, and Multi-Omics for <em>In Silico</em> Oncology and Precision TheranosticsSemantic proximity Read

An integrated multi-omics investigation of W-NK1, a cytokine-primed non-engineered natural killer cell therapy productSemantic proximity Read

CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read

BioAgent: An Auditable Multi-Agent Framework for Reproducible Translational BioinformaticsSemantic proximity Read

Leveraging Single-Cell Sequencing for Chimeric Antigen Receptor T Cell TherapiesSemantic proximity Read

IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome DiscoverySemantic proximity Read

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interfaceSemantic proximity Read