Article

No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk

2025-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Estrogen receptor-positive breast cancer (ER+ BC) is one of the most prevalent cancers, but the evolutionary processes shaping genetic variation in ER+ BC risk are poorly understood. Both evolutionary life-history theory and evidence from studies of individual ER+ BC risk variants suggest that increased genetic ER+ BC risk is associated with faster maturation, earlier reproduction, and/or increa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 830c477c-d27d-5292-a73d-f9ba1bd5b958
DOI: 10.1101/2025.06.26.661731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer riskDOI 10.1101/2025.06.26.661731Read

Reproductive windows, genetic loci, and breast cancer risk.Semantic proximity Read

Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis.Semantic proximity Read

Reproductive aging-associated common genetic variants and the risk of breast cancer.Semantic proximity Read

Why do we get sick? Genetic evidence for evolutionary trade-offs between fertility, longevity, and diseaseSemantic proximity Read

Human Fertility, Molecular Genetics, and Natural Selection in Modern SocietiesSemantic proximity Read

A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.Semantic proximity Read

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study.Semantic proximity Read

Previous GWAS hits in relation to young-onset breast cancer.Semantic proximity Read

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study.Semantic proximity Read

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.Semantic proximity Read

Genetic links between post-reproductive lifespan and family size in FraminghamSemantic proximity Read

The relationships between women’s reproductive factors: a Mendelian randomization analysisSemantic proximity Read