Endoplasmic reticulum–associated degradation is required for nephrin maturation and kidney glomerular filtration function

Abstract excerpt

Podocytes are key to the glomerular filtration barrier by forming a slit diaphragm between interdigitating foot processes; however, the molecular details and functional importance of protein folding and degradation in the ER remain unknown. Here, we show that the SEL1L-HRD1 protein complex of ER-associated degradation (ERAD) is required for slit diaphragm formation and glomerular filtration function. SEL1L-HRD1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomedical Research and Pathophysiology
• Share to Genetic and Kidney Cyst Diseases
• Share to Renal Diseases and Glomerulopathies